Publication Date:
1999-01-29
Description:
Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viola, A -- Schroeder, S -- Sakakibara, Y -- Lanzavecchia, A -- New York, N.Y. -- Science. 1999 Jan 29;283(5402):680-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland. viola@bii.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9924026" target="_blank"〉PubMed〈/a〉
Keywords:
Antigen-Presenting Cells/immunology
;
Antigens, CD28/immunology/*metabolism
;
Antigens, CD3/immunology
;
Cell Membrane/metabolism
;
G(M1) Ganglioside/metabolism
;
Humans
;
*Lymphocyte Activation
;
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism
;
Membrane Lipids/*metabolism
;
Phosphorylation
;
Phosphotyrosine/metabolism
;
Receptors, Antigen, T-Cell/immunology/*metabolism
;
Signal Transduction
;
T-Lymphocytes/*immunology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
