Publication Date:
1998-09-11
Description:
Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells. In vitro and in vivo assays revealed that leptin has angiogenic activity. In vivo, leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which lack functional leptin receptors. These observations indicate that the vascular endothelium is a target for leptin and suggest a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sierra-Honigmann, M R -- Nath, A K -- Murakami, C -- Garcia-Cardena, G -- Papapetropoulos, A -- Sessa, W C -- Madge, L A -- Schechner, J S -- Schwabb, M B -- Polverini, P J -- Flores-Riveros, J R -- New York, N.Y. -- Science. 1998 Sep 11;281(5383):1683-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA. rocio_sierra-honigmann@qm.yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9733517" target="_blank"〉PubMed〈/a〉
Keywords:
Adipocytes/metabolism
;
Amino Acid Sequence
;
Animals
;
Carrier Proteins/analysis/*physiology
;
Cells, Cultured
;
Corneal Neovascularization
;
DNA-Binding Proteins/metabolism
;
Endothelial Growth Factors/pharmacology
;
Endothelium, Vascular/chemistry/cytology/*physiology
;
Energy Metabolism
;
Humans
;
Leptin
;
Lipid Metabolism
;
Lymphokines/pharmacology
;
Molecular Sequence Data
;
*Neovascularization, Physiologic
;
Phosphorylation
;
Proteins/pharmacology/*physiology
;
Rats
;
Rats, Zucker
;
*Receptors, Cell Surface
;
Receptors, Leptin
;
STAT3 Transcription Factor
;
Trans-Activators/metabolism
;
Vascular Endothelial Growth Factor A
;
Vascular Endothelial Growth Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
