Publication Date:
1998-09-04
Description:
Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein trigger repulsive turning responses by growth cones of cultured Xenopus spinal neurons; the repulsion can be converted to attraction by pharmacological activation of the guanosine 3',5'-monophosphate (cGMP) and adenosine 3',5'-monophosphate signaling pathways, respectively. Sema III also causes the collapse of cultured rat sensory growth cones, which can be inhibited by activation of the cGMP pathway. Thus cyclic nucleotides can regulate growth cone behaviors and may be targets for designing treatments to alleviate the inhibition of nerve regeneration by repulsive factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Song, H -- Ming, G -- He, Z -- Lehmann, M -- McKerracher, L -- Tessier-Lavigne, M -- Poo, M -- NS22764/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1998 Sep 4;281(5382):1515-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California at San Diego, La Jolla, CA 92093-0357, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9727979" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/physiology
;
Calcium/physiology
;
Cells, Cultured
;
Cyclic AMP/analogs & derivatives/pharmacology/*physiology
;
Cyclic GMP/analogs & derivatives/pharmacology/*physiology
;
Ganglia, Spinal/cytology
;
Glycoproteins/*physiology
;
Myelin-Associated Glycoprotein/physiology
;
Nerve Growth Factors/*physiology
;
Nerve Tissue Proteins/physiology
;
Neurites/*physiology
;
Neurons/cytology/*physiology
;
Neuropilin-1
;
Rats
;
Recombinant Proteins
;
Semaphorin-3A
;
Spinal Cord/cytology
;
Thionucleotides/pharmacology
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
