Publication Date:
1998-07-31
Description:
Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, D M -- Forsthuber, T -- Tary-Lehmann, M -- Etling, C -- Ito, K -- Nagy, Z A -- Field, J A -- Steere, A C -- Huber, B T -- R01 AR20358/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jul 31;281(5377):703-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Tufts University, Boston, MA 02111 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9685265" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Algorithms
;
Amino Acid Sequence
;
Animals
;
Antigen Presentation
;
Antigens, Surface/immunology/metabolism
;
Arthritis, Reactive/drug therapy/*immunology
;
Autoantigens/*immunology
;
Autoimmune Diseases/*immunology
;
Bacterial Outer Membrane Proteins/immunology/metabolism
;
Bacterial Vaccines
;
Borrelia burgdorferi Group/immunology
;
Child
;
Cross Reactions
;
Female
;
HLA-DR Antigens/genetics/immunology/metabolism
;
HLA-DRB1 Chains
;
Humans
;
Immunodominant Epitopes
;
*Lipoproteins
;
Lyme Disease/drug therapy/*immunology
;
Lymphocyte Function-Associated Antigen-1/chemistry/*immunology/metabolism
;
Male
;
Mice
;
Mice, Transgenic
;
Molecular Sequence Data
;
Synovial Fluid/immunology
;
T-Lymphocytes, Helper-Inducer/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
