Publication Date:
1998-05-09
Description:
Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamond, A I -- Earnshaw, W C -- 073915/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1998 Apr 24;280(5363):547-53.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, UK. a.i.lamond@dundee.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9554838" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Nucleolus/physiology/ultrastructure
;
Cell Nucleus/chemistry/*physiology/*ultrastructure
;
Chromatin/physiology
;
Chromosomes/physiology
;
*Drosophila Proteins
;
Euchromatin
;
Gene Expression Regulation
;
Heterochromatin/physiology
;
Humans
;
Insect Proteins/chemistry/physiology
;
Interphase
;
Neoplasm Proteins/chemistry/physiology
;
*Nuclear Proteins
;
Polycomb Repressive Complex 1
;
Polycomb-Group Proteins
;
Repressor Proteins/chemistry/physiology
;
Ribonucleoproteins, Small Nuclear/analysis/physiology
;
Transcription Factors/chemistry/physiology
;
Tumor Suppressor Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
