Publication Date:
1998-03-07
Description:
The mechanisms by which Ebola virus evades detection and infects cells to cause hemorrhagic fever have not been defined, though its glycoprotein, synthesized in either a secreted or transmembrane form, is likely involved. Here the secreted glycoprotein was found to interact with neutrophils through CD16b, the neutrophil-specific form of the Fc gamma receptor III, whereas the transmembrane glycoprotein was found to interact with endothelial cells but not neutrophils. A murine retroviral vector pseudotyped with the transmembrane glycoprotein preferentially infected endothelial cells. Thus, the secreted glycoprotein inhibits early neutrophil activation, which likely affects the host response to infection, whereas binding of the transmembrane glycoprotein to endothelial cells may contribute to the hemorrhagic symptoms of this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Z -- Delgado, R -- Xu, L -- Todd, R F -- Nabel, E G -- Sanchez, A -- Nabel, G J -- New York, N.Y. -- Science. 1998 Feb 13;279(5353):1034-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9461435" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Line
;
Ebolavirus/genetics/metabolism/*pathogenicity/physiology
;
Endothelium, Vascular/cytology/*metabolism/virology
;
Genes, Viral
;
Genetic Vectors
;
Glycoproteins/genetics/*metabolism/secretion
;
Hemorrhagic Fever, Ebola/virology
;
Humans
;
L-Selectin/metabolism
;
Membrane Glycoproteins/genetics/*metabolism
;
Moloney murine leukemia virus/genetics/physiology
;
Neutrophil Activation
;
Neutrophils/immunology/*metabolism
;
Receptors, IgG/metabolism
;
Transfection
;
Tumor Cells, Cultured
;
Viral Matrix Proteins/genetics/*metabolism
;
Viral Proteins/genetics/*metabolism/secretion
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
