Publication Date:
1998-02-07
Description:
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ilver, D -- Arnqvist, A -- Ogren, J -- Frick, I M -- Kersulyte, D -- Incecik, E T -- Berg, D E -- Covacci, A -- Engstrand, L -- Boren, T -- New York, N.Y. -- Science. 1998 Jan 16;279(5349):373-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Umea University, SE-901 87 Umea, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9430586" target="_blank"〉PubMed〈/a〉
Keywords:
Adhesins, Bacterial/chemistry/genetics/*isolation & purification/metabolism
;
Amino Acid Sequence
;
*Antigens, Bacterial
;
Bacterial Adhesion
;
Bacterial Proteins/genetics/physiology
;
Base Composition
;
Base Sequence
;
Biotinylation
;
Cell Membrane/chemistry
;
Cloning, Molecular
;
Codon, Initiator
;
Fucose
;
Gastric Mucosa/microbiology
;
Genes, Bacterial
;
Glycoconjugates/metabolism
;
Helicobacter pylori/isolation & purification/*metabolism/pathogenicity
;
Humans
;
Lewis Blood-Group System/*metabolism
;
Ligands
;
Molecular Sequence Data
;
Virulence
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
