Publication Date:
1996-12-20
Description:
Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up-regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vieira, A V -- Lamaze, C -- Schmid, S L -- CA58689/CA/NCI NIH HHS/ -- CA69099/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2086-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. slschmid@scripps.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8953040" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptor Proteins, Signal Transducing
;
*Adaptor Proteins, Vesicular Transport
;
Calcium-Calmodulin-Dependent Protein Kinases/metabolism
;
Cell Division/drug effects
;
Cell Membrane/metabolism
;
Clathrin/*physiology
;
Coated Pits, Cell-Membrane/physiology
;
Dynamins
;
*Endocytosis
;
Enzyme Activation
;
Epidermal Growth Factor/metabolism/pharmacology
;
GTP Phosphohydrolases/physiology
;
HeLa Cells
;
Humans
;
Isoenzymes/metabolism
;
Phosphatidylinositol 3-Kinases
;
Phospholipase C gamma
;
Phosphorylation
;
Phosphotransferases (Alcohol Group Acceptor)/metabolism
;
Phosphotyrosine/metabolism
;
Proteins/metabolism
;
Receptor, Epidermal Growth Factor/*metabolism
;
Shc Signaling Adaptor Proteins
;
*Signal Transduction
;
Type C Phospholipases/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
