Publication Date:
1993-03-26
Description:
Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LeMasson, G -- Marder, E -- Abbott, L F -- MH46742/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1993 Mar 26;259(5103):1915-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Brandeis University, Waltham, MA 02254.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8456317" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/*metabolism/pharmacology
;
Electric Conductivity
;
Electric Stimulation
;
Feedback
;
*Models, Biological
;
Neurons/drug effects/*physiology
;
Potassium/metabolism/pharmacology
;
Second Messenger Systems
;
Sodium/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
