Publication Date:
1993-03-12
Description:
Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shing, Y -- Christofori, G -- Hanahan, D -- Ono, Y -- Sasada, R -- Igarashi, K -- Folkman, J -- CA 70118/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1993 Mar 12;259(5101):1604-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgery, Children's Hospital, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8456283" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells
;
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Betacellulin
;
Cell Division/drug effects
;
Cells, Cultured
;
DNA Replication/drug effects
;
Endothelium, Vascular/cytology/drug effects
;
Epidermal Growth Factor/pharmacology
;
Growth Substances/*genetics/isolation & purification/pharmacology
;
Humans
;
*Intercellular Signaling Peptides and Proteins
;
Islets of Langerhans/physiopathology
;
Kinetics
;
Mice
;
Molecular Sequence Data
;
Muscle, Smooth, Vascular/cytology/drug effects
;
Oligodeoxyribonucleotides
;
Pancreatic Neoplasms/*physiopathology
;
Pigment Epithelium of Eye/cytology/drug effects
;
Polymerase Chain Reaction/methods
;
Protein Precursors/genetics
;
Rats
;
Receptor, Epidermal Growth Factor/metabolism
;
Recombinant Proteins/pharmacology
;
Sequence Homology, Amino Acid
;
Thymidine/metabolism
;
Transforming Growth Factor alpha/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
