Publication Date:
1993-07-16
Description:
Propagating Ca2+ waves are a characteristic feature of Ca(2+)-linked signal transduction pathways. Intracellular Ca2+ waves are formed by regenerative stimulation of Ca2+ release from intracellular stores by Ca2+ itself. Mechanisms that rely on either inositol trisphosphate or ryanodine receptor channels have been proposed to account for Ca2+ waves in various cell types. Both channel types contributed to the Ca2+ wave during fertilization of sea urchin eggs. Alternative mechanisms of Ca2+ release imply redundancy but may also allow for modulation and diversity in the generation of Ca2+ waves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galione, A -- McDougall, A -- Busa, W B -- Willmott, N -- Gillot, I -- Whitaker, M -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1993 Jul 16;261(5119):348-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Oxford University, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8392748" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Diphosphate Ribose/analogs & derivatives/pharmacology
;
Adenosine Triphosphate/metabolism
;
Animals
;
Caffeine/pharmacology
;
Calcium/*metabolism/pharmacology
;
*Calcium Channels
;
Cyclic ADP-Ribose
;
Female
;
*Fertilization
;
Heparin/pharmacology
;
Inositol 1,4,5-Trisphosphate/pharmacology
;
Inositol 1,4,5-Trisphosphate Receptors
;
Muscle Proteins/drug effects/*physiology
;
Ovum/drug effects/*metabolism
;
Receptors, Cell Surface/drug effects/*physiology
;
*Receptors, Cytoplasmic and Nuclear
;
Ryanodine/pharmacology
;
Ryanodine Receptor Calcium Release Channel
;
Sea Urchins
;
Signal Transduction
;
Thimerosal/pharmacology
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
