Publication Date:
1993-09-10
Description:
Expression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes. A null mutation in the gene encoding CD4 impairs the development of the helper cell lineage that is normally defined by CD4 expression. Infection of CD4-null mice with Leishmania has revealed a population of functional helper T cells that develops despite the absence of CD4. These CD8- alpha beta T cell receptor+ T cells are major histocompatibility complex class II-restricted and produce interferon-gamma when challenged with parasite antigens. These results indicate that T lymphocyte lineage commitment and peripheral function need not depend on the function of CD4.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Locksley, R M -- Reiner, S L -- Hatam, F -- Littman, D R -- Killeen, N -- AI30663/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1993 Sep 10;261(5127):1448-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Francisco 94143-0654.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8367726" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD4/genetics/*immunology
;
Antigens, CD8/immunology
;
Antigens, Protozoan/immunology
;
B-Lymphocytes/immunology
;
Base Sequence
;
CD4-CD8 Ratio
;
Histocompatibility Antigens Class II/immunology
;
Hypersensitivity, Delayed
;
Interferon-gamma/biosynthesis/immunology
;
Leishmania tropica/*immunology
;
Leishmaniasis, Cutaneous/*immunology
;
Mice
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Mutation
;
Oligodeoxyribonucleotides
;
Receptors, Antigen, T-Cell, alpha-beta/immunology
;
T-Lymphocytes/immunology
;
T-Lymphocytes, Helper-Inducer/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
