Publication Date:
1993-07-02
Description:
Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mozes, E -- Kohn, L D -- Hakim, F -- Singer, D S -- New York, N.Y. -- Science. 1993 Jul 2;261(5117):91-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8316860" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Antinuclear/immunology
;
Antibodies, Monoclonal/immunology
;
Histocompatibility Antigens Class I/*immunology
;
Immunity, Innate
;
Immunization
;
Immunoglobulin Idiotypes/immunology
;
Lupus Erythematosus, Systemic/*immunology
;
Mice
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
