Publication Date:
1993-12-17
Description:
Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shrivastava, A -- Saleque, S -- Kalpana, G V -- Artandi, S -- Goff, S P -- Calame, K -- CA 38571/CA/NCI NIH HHS/ -- GM29361/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 17;262(5141):1889-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266081" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells
;
Adenovirus E1A Proteins/metabolism
;
Animals
;
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
;
Basic-Leucine Zipper Transcription Factors
;
DNA-Binding Proteins/antagonists & inhibitors/genetics/*metabolism/pharmacology
;
Erythroid-Specific DNA-Binding Factors
;
Helix-Loop-Helix Motifs
;
Humans
;
Mice
;
Proto-Oncogene Proteins c-myc/*metabolism/pharmacology
;
Recombinant Fusion Proteins/metabolism
;
Transcription Factors/antagonists & inhibitors/genetics/*metabolism/pharmacology
;
Transfection
;
Tumor Cells, Cultured
;
Upstream Stimulatory Factors
;
YY1 Transcription Factor
;
*Zinc Fingers
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
