Publication Date:
1994-09-16
Description:
After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point mutations in which allow expression to spread into adjacent rhombomeres. Retinoids and their nuclear receptors may therefore participate in sharpening segment-restricted expression of Hoxb-1 during rhombomere boundary formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Studer, M -- Popperl, H -- Marshall, H -- Kuroiwa, A -- Krumlauf, R -- New York, N.Y. -- Science. 1994 Sep 16;265(5179):1728-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lab of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7916164" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Chick Embryo
;
Enhancer Elements, Genetic
;
Gene Expression Regulation
;
*Genes, Homeobox
;
Mice
;
Mice, Transgenic
;
Molecular Sequence Data
;
Neural Crest/metabolism
;
Oligonucleotides/metabolism
;
Point Mutation
;
Receptors, Cytoplasmic and Nuclear/metabolism
;
Receptors, Retinoic Acid/metabolism
;
*Regulatory Sequences, Nucleic Acid
;
Retinoid X Receptors
;
Rhombencephalon/*embryology/metabolism
;
*Transcription Factors
;
Tretinoin/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
