Publication Date:
1981-09-25
Description:
Total concentrations of estrogen receptor in the uterine nuclear fraction are reduced rapidly after progesterone treatment of the proestrous hamster. Progesterone acts selectively on the occupied form of the nuclear estrogen receptor, with no effect on the concentration of an unoccupied form. This observation indicates that progesterone modulates the action of estrogen by controlling nuclear retention of the estrogen-receptor complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okulicz, W C -- Evans, R W -- Leavitt, W W -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1503-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280669" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Nucleus/metabolism
;
Cricetinae
;
Cytosol/metabolism
;
Estradiol/metabolism
;
Female
;
Progesterone/*pharmacology
;
Receptors, Estrogen/*drug effects/metabolism
;
Uterus/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
