Publication Date:
1981-07-10
Description:
Testosterone is converted in the dove (Streptopelia risoria) brain to 5 beta-reduced metabolites that do not affect behavior. In long-term castrated birds, which are relatively insensitive to the behavioral effects of testosterone, the activity of preoptic 5 beta-reductase is increased. The increase, which is specific to the preoptic area, is reversed by estrogen. Inactivation of testosterone by 5 beta-reduction may be involved in the control of brain sensitivity to androgen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hutchison, J B -- Steimer, T -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):244-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244635" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/*drug effects
;
Birds
;
Brain/drug effects/*enzymology
;
Castration
;
Diethylstilbestrol/*pharmacology
;
Oxidoreductases/*metabolism
;
Testosterone/*pharmacology
;
Vocalization, Animal
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
