Publication Date:
1983-01-07
Description:
Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock. These treatments may facilitate cyclase activation by promoting the interaction of the regulatory and catalytic subunits of the enzyme. This finding suggests a possible mechanism for the changes in sensitivity to various neurotransmitters seen after antidepressant administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Menkes, D B -- Rasenick, M M -- Wheeler, M A -- Bitensky, M W -- AM 06287/AM/NIADDK NIH HHS/ -- AM 20179/AM/NIADDK NIH HHS/ -- GM 07205/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849117" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/*metabolism
;
Animals
;
Antidepressive Agents, Tricyclic/*pharmacology
;
Brain/*enzymology
;
Cell Membrane/metabolism
;
Electroconvulsive Therapy
;
Enzyme Activation
;
Guanosine Triphosphate/*pharmacology
;
Male
;
Organ Specificity
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
