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  • 1
    Publication Date: 1978-07-14
    Description: 3-Methylindole, a ruminal fermentation product of tryptophan, induces acute pulmonary edema and emphysema in cattle, and 3-methylindole is present in the ruminal fluid and blood of cows with a natually occurring form of this disease. Monensin, a polyether antibiotic and widely used feed additive for beef cattle, prevented tryptophan-induced acute bovine pulmonary edema and emphysema. Monensin acted by reducing the ruminal conversion of L-tryptophan to 3-methylindole both in vitro and in vivo. Lasalocid, also a polyether antibiotic, showed similar effects in vitro. These results provide a promising approach to prevention of this major respiratory disease of cattle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hammond, A C -- Carlson, J R -- Breeze, R G -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):153-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663643" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Furans/*therapeutic use ; Lasalocid/therapeutic use ; Monensin/pharmacology/*therapeutic use ; Pneumonia, Atypical Interstitial, of Cattle/*prevention & control ; Rumen/metabolism ; Skatole/metabolism ; Tryptophan/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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