Publication Date:
1980-09-12
Description:
The interaction of endogenous opiates and stress-induced eating in rats was evaluated by pharmacological manipulation. Eating induced by the tail-pinch method was inhibited by the opitate antagonist naloxone; after being repeatedly stressed over a 10-day period and then given nalozone, the rats behaved in a manner indistinguishable from the "wet-dog" shakes of opiate withdrawal. Thus endogenous opiates may have a role in the control of stress-related eating, a finding that may have therapeutic implications for humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morley, J E -- Levine, A S -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250222" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Cholecystokinin/pharmacology
;
Diazepam/pharmacology
;
Eating/*drug effects
;
Endorphins/antagonists & inhibitors/*physiology
;
Male
;
Naloxone/*pharmacology
;
Rats
;
Receptors, Opioid/drug effects
;
Stress, Physiological/*physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
