Publication Date:
1980-01-04
Description:
Morphine and beta-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and beta-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Craves, F B -- Zalc, B -- Leybin, L -- Baumann, N -- Loh, H H -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):75-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243189" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Antibody Reactions
;
Behavior, Animal/drug effects
;
Biological Assay
;
Brain/*immunology
;
Cerebral Aqueduct
;
Endorphins/*antagonists & inhibitors
;
Male
;
Morphine/*antagonists & inhibitors
;
Pentobarbital/pharmacology
;
Rats
;
Receptors, Opioid/*immunology
;
Sulfoglycosphingolipids/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
