Publication Date:
1984-11-02
Description:
There is evidence that substance P is a peptide neurotransmitter of some unmyelinated primary afferent nociceptors and that its release from the peripheral terminals of primary afferent fibers mediates neurogenic inflammation. The investigators examined whether substance P also contributes to the severity of adjuvant-induced arthritis, an inflammatory disease in rats. They found that, in the rat, joints that developed more severe arthritis (ankles) were more densely innervated by substance P-containing primary afferent neurons than were joints that developed less severe arthritis (knees). Infusion of substance P into the knee increased the severity of arthritis; injection of a substance P receptor antagonist did not. These results suggest a significant physiological difference between joints that develop mild and severe arthritis and indicate that release of intraneuronal substance P in joints contributes to the severity of the arthritis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, J D -- Clark, R -- Devor, M -- Helms, C -- Moskowitz, M A -- Basbaum, A I -- AM 32634/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):547-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6208609" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arthritis/chemically induced/*physiopathology
;
Double-Blind Method
;
Hindlimb
;
Joints/drug effects/innervation/physiopathology
;
Neurons, Afferent/physiology
;
Rats
;
Substance P/pharmacology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
