Publication Date:
1978-01-27
Description:
Electron microscopic evidence of early atherogenic changes in the aorta and coronary arteries was obtained in normal fed, conscious, unrestrained rats receiving electrical stimulation in the lateral hypothalamus for periods of up to 62 days. Hypertension and hypercholesterolemia were not etiologic factors. In view of recent observations concerning neuropsychological mechanisms in human ischemic heart disease, the findings raise the possibility that the human central nervous system has a role in the development of atherosclerotic lesions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gutstein, W H -- Harrison, J -- Parl, F -- Ku, G -- Avtable, M -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619468" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aorta/pathology
;
Arteriosclerosis/*etiology/pathology/physiopathology
;
Blood Pressure
;
Cholesterol/blood
;
Coronary Vessels/pathology
;
*Disease Models, Animal
;
Electric Stimulation
;
Hypothalamus/*physiopathology
;
Male
;
Rats
;
Stress, Physiological/*complications
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
