Publication Date:
1982-06-11
Description:
A new human erythroleukemia cell line has been established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly G gamma and A gamma chains. Embryonic chains (epsilon, zeta) and alpha chains are detectable in very small amounts; beta chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, P -- Papayannopoulou, T -- CA 18029/CA/NCI NIH HHS/ -- HL 20899/HL/NHLBI NIH HHS/ -- P01 CA018029/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1233-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177045" target="_blank"〉PubMed〈/a〉
Keywords:
*Cell Line
;
Fetal Hemoglobin/genetics
;
Gene Expression Regulation/drug effects
;
Globins/*biosynthesis/genetics
;
Hemin/pharmacology
;
Humans
;
Karyotyping
;
Leukemia, Erythroblastic, Acute/genetics/*metabolism
;
Neoplasms, Experimental/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
