Publication Date:
1983-01-21
Description:
Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs. The ability of somatostatin to inhibit acid secretion was blocked by indomethacin, an inhibitor of prostaglandin synthesis. These results suggest that prostaglandins mediate gastric acid inhibition by somatostatin in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ligumsky, M -- Goto, Y -- Debas, H -- Yamada, T -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6129701" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carbachol/pharmacology
;
Cyclic AMP/biosynthesis
;
Gastric Juice/*secretion
;
Indomethacin/pharmacology
;
Male
;
Prostaglandins/*physiology
;
Rats
;
Receptors, Cholinergic/*physiology
;
Receptors, Muscarinic/*physiology
;
Somatostatin/*pharmacology
;
Stomach/innervation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
