Publication Date:
1981-03-06
Description:
Somatostatin, the growth hormone-inhibiting factor, when microinjected into the third ventricle of the rat brain, paradoxically induced the release of growth hormone. A pituitary site of action having been ruled out, this result supports the concept that exogenous somatostatin within the hypothalamus acts either to suppress the release of somatostatin from somatostatin-containing neurons, possibly via an ultrashort-loop feedback mechanism, or to augment release of hypothalamic growth hormone-releasing factor, thereby inducing a release of growth hormone. Injection of somatostatin into the third ventricle also decreased plasma concentrations of luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone, probably by inhibiting the release of luteinizing hormone-releasing factor and thyrotropin-releasing factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lumpkin, M D -- Gegro-Vilar, A -- McCann, S M -- AM-10073/AM/NIADDK NIH HHS/ -- HD-07062/HD/NICHD NIH HHS/ -- HD-09988/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1072-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6110244" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Castration
;
Female
;
Follicle Stimulating Hormone/blood
;
Growth Hormone/*secretion
;
Hypothalamus/*drug effects/secretion
;
Injections, Intraventricular
;
Luteinizing Hormone/blood
;
Metabolic Clearance Rate
;
Rats
;
Somatostatin/administration & dosage/*pharmacology
;
Thyrotropin/blood
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
