Publication Date:
1984-10-26
Description:
Procedures have now been developed for inserting functional genes into the bone marrow of mice. The most effective delivery system at present uses retroviral-based vectors to transfer a gene into murine bone marrow cells in culture. The genetically altered bone marrow is then implanted into recipient animals. These somatic cell gene therapy techniques are becoming increasingly efficient. Their future application in humans should result in at least partial correction of a number of genetic disorders. However, the safety of the procedures must still be established by further animal studies before human clinical trials would be ethical.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, W F -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):401-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093246" target="_blank"〉PubMed〈/a〉
Keywords:
Animal Experimentation
;
Bone Marrow
;
Containment of Biohazards
;
DNA Viruses/genetics
;
*DNA, Recombinant
;
Ethics Committees, Research
;
Ethics, Medical
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Federal Government
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Gene Expression Regulation
;
*Genes
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Genetic Diseases, Inborn/*therapy
;
*Genetic Engineering
;
Genetic Vectors
;
Government Regulation
;
Humans
;
Microinjections
;
Operon
;
Plasmids
;
Retroviridae/genetics
;
Risk Assessment
;
Skin
;
Transcription, Genetic
;
future clinical trials in humans are being debated among scientists and policy
;
makers. Anderson, chief of the Laboratory of Molecular Hematology at the National
;
Heart, Lung, and Blood Institute, examines how soon gene therapy might be
;
available for the treatment of diseases in humans, and what criteria should be
;
met before experimentation with human subjects begins. He identifies delivery,
;
gene expression, and safety as the three requisites that must be satisfied, and
;
reviews the animal work that has been done in these areas. Human trials should
;
begin only after more animal studies have demonstrated to local and federal
;
review committees that gene therapy is safe and offers the possibility of benefit
;
to patients.
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
