Publication Date:
1984-09-07
Description:
Four surface antigens previously recognized only in macrophages are present on human small cell lung carcinoma cells and tumors. Cancerous cells may arise from macrophage precursors in bone marrow, and these precursors migrate to lung to participate in the repair of damaged tissue produced by continuous heavy smoking. The characteristic presence of neuropeptides such as bombesin in small cell carcinoma, when considered along with these findings, presents new possibilities for the role of such peptides in nervous, endocrine, and immune system function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruff, M R -- Pert, C B -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1034-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089338" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, Neoplasm/*analysis
;
Antigens, Surface/*analysis
;
Carcinoma, Small Cell/etiology/*immunology/pathology
;
Cell Line
;
Cell Transformation, Neoplastic
;
*Hematopoietic Stem Cells
;
Humans
;
Lung Neoplasms/etiology/*immunology/pathology
;
Macrophages/*immunology
;
Monocytes/pathology
;
Smoking
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
