Publication Date:
1986-01-24
Description:
When platelets were incubated with prostacyclin, prostaglandin E1, or prostaglandin D2 at concentrations insufficient to increase the level of adenosine 3',5'-monophosphate (cyclic AMP), coagulation factor X was activated by a platelet cysteine protease. Prostacyclin or prostaglandin E1 at higher concentrations increased the cyclic AMP level and inhibited the activation of factor X by platelets. Inhibition of platelet adenylate cyclase by 2',5'-dideoxyadenosine allowed the activation of the protease at higher concentrations of the autocoids. Prostaglandins A1, A2, B1, B2, E2, F2 alpha, 6-keto-prostaglandin F1 alpha, and thromboxane B2, which do not affect platelet cyclic AMP level, did not stimulate the protease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dutta-Roy, A K -- Ray, T K -- Sinha, A K -- New York, N.Y. -- Science. 1986 Jan 24;231(4736):385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3001935" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/metabolism
;
Alprostadil/pharmacology
;
Animals
;
Blood Platelets/*drug effects/metabolism/physiology
;
Cattle
;
Cyclic AMP/metabolism
;
Deoxyadenosines/analogs & derivatives/pharmacology
;
*Dideoxyadenosine/*analogs & derivatives
;
Epoprostenol/*pharmacology
;
Factor X/*physiology
;
Humans
;
Peptide Hydrolases/metabolism
;
Prostaglandin D2
;
Prostaglandins/pharmacology
;
Prostaglandins D/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
