Publication Date:
1985-04-12
Description:
Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Desrosiers, R C -- Bakker, A -- Kamine, J -- Falk, L A -- Hunt, R D -- King, N W -- 26225/PHS HHS/ -- 31363/PHS HHS/ -- RR00168/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1985 Apr 12;228(4696):184-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2983431" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aotus trivirgatus
;
DNA, Recombinant/metabolism
;
DNA, Viral/genetics
;
Genes, Viral
;
Herpesviridae Infections/genetics
;
Herpesvirus 2, Saimiriine/*genetics
;
Lymph Nodes/pathology
;
Lymphocytes/microbiology
;
*Oncogenes
;
Tumor Virus Infections/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
