Publication Date:
1989-09-29
Description:
Human malignant cells secrete low molecular size proteins that attract peripheral blood monocytes and may be responsible for the accumulation of tumor-associated macrophages observed in vivo. Similar chemotactic proteins are secreted by cultured vascular smooth muscle cells. The predominant monocyte chemoattractants produced by tumor cells of differing origin were demonstrated to be related to smooth muscle cell-derived chemotactic factor. Thus, a single class of chemotactic proteins is produced by different cell types, which suggests a common mechanism for the recruitment of monocytes and macrophages. These results are significant in view of the potential of macrophages to affect tumor growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graves, D T -- Jiang, Y L -- Williamson, M J -- Valente, A J -- DE-07559/DE/NIDCR NIH HHS/ -- DE-08569/DE/NIDCR NIH HHS/ -- HL-38390/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 29;245(4925):1490-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oral Biology, Boston University Medical Center, MA 02118.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2781291" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chemotactic Factors/*biosynthesis
;
*Chemotaxis, Leukocyte
;
Humans
;
Monocytes/*cytology
;
Muscle, Smooth, Vascular/*metabolism
;
Papio
;
Precipitin Tests
;
Tumor Cells, Cultured/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
