Publication Date:
1989-09-22
Description:
Long-term potentiation (LTP) is a model for learning and memory processes. Tetanic stimulation of the sensory cortex produces LTP in motor cortical neurons, whereas tetanization of the ventrolateral nucleus of the thalamus, which also projects to the motor cortex, does not. However, after simultaneous high-frequency stimulation of both the sensory cortex and the ventrolateral nucleus of the thalamus, LTP of thalamic input to motor cortical neurons is induced. This associative LTP occurs only in neurons in the superficial layers of the motor cortex that receive monosynaptic input from both the sensory cortex and the ventrolateral nucleus of the thalamus. Associative LTP in the motor cortex may constitute a basis for the retention of motor skills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iriki, A -- Pavlides, C -- Keller, A -- Asanuma, H -- NS-08626/NS/NINDS NIH HHS/ -- NS-10705/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 22;245(4924):1385-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rockefeller University, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2551038" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain Mapping
;
Cats
;
Electric Stimulation
;
Learning/physiology
;
Motor Cortex/*physiology
;
*Motor Skills
;
Somatosensory Cortex/physiology
;
Synaptic Transmission
;
Thalamic Nuclei/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
