Publication Date:
1990-12-07
Description:
Virus envelope (Env) proteins are thought to contain specific signals for selective uptake by virus particles. In the course of attempting to define these signals by testing virus incorporation of CD4-Env chimeric proteins, normal human CD4 was found to be efficiently and selectively assembled into avian leukosis virus particles in quail cells. Viruses bearing CD4 at their surface may be useful reagents in the design of retrovirus-mediated gene therapy for the acquired immune deficiency syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, J A -- Bates, P -- Willert, K -- Varmus, H E -- New York, N.Y. -- Science. 1990 Dec 7;250(4986):1421-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of California School of Medicine, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2175047" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD4/*genetics
;
Avian Leukosis Virus/*genetics
;
Cell Line
;
Chimera
;
Humans
;
Quail
;
Transfection
;
Viral Envelope Proteins/*genetics
;
Virion/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics