Publication Date:
1991-10-25
Description:
Early in the process of spore formation in Bacillus subtilis a septum is formed that partitions the sporangium into daughter cells called the forespore and the mother cell. The daughter cells each have their own chromosome but follow dissimilar programs of gene expression. Differential gene expression in the forespore is now shown to be established by the compartmentalized activity of the transcription factor sigma F. The sigma F factor is produced prior to septation, but is active only in the forespore compartment of the post-septation sporangium. The sigma F factor is controlled by the products of sporulation operons spoIIA and spoIIE, which may be responsible for confining its activity to one of the daughter cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margolis, P -- Driks, A -- Losick, R -- GM18568/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Oct 25;254(5031):562-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948031" target="_blank"〉PubMed〈/a〉
Keywords:
Bacillus subtilis/cytology/genetics/*physiology
;
Cloning, Molecular
;
*Gene Expression Regulation, Bacterial
;
Microscopy, Immunoelectron
;
Mutagenesis, Site-Directed
;
*Operon
;
Sigma Factor/*physiology
;
Spores, Bacterial/physiology/ultrastructure
;
beta-Galactosidase/biosynthesis/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
