Publication Date:
1978-01-06
Description:
Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total protein and albumin synthesis and release from C4-deficient polysomes were similar to that in normal guinea pig liver polysomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, R E -- Colten, H R -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):69-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ina Sue Perlmutter Cystic Fibrosis Center, Children's Hospital Medical Center, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569484" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell-Free System
;
Complement C4/*biosynthesis/deficiency/*genetics
;
Guinea Pigs
;
Immunoprecipitation
;
Liver/immunology/*metabolism
;
Polyribosomes/immunology/*metabolism
;
Protein Biosynthesis
;
RNA, Messenger/*genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
