Publication Date:
1999-06-12
Description:
The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bermingham, N A -- Hassan, B A -- Price, S D -- Vollrath, M A -- Ben-Arie, N -- Eatock, R A -- Bellen, H J -- Lysakowski, A -- Zoghbi, H Y -- R01 DC002290/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 1999 Jun 11;284(5421):1837-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10364557" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basic Helix-Loop-Helix Transcription Factors
;
Calbindin 2
;
Cell Differentiation
;
Cochlea/embryology/metabolism/ultrastructure
;
Ear, Inner/*embryology/metabolism/ultrastructure
;
Epithelium/metabolism/ultrastructure
;
Gene Expression Regulation, Developmental
;
Gene Targeting
;
*Genes, Essential
;
Hair Cells, Auditory, Inner/*cytology/metabolism
;
Mice
;
Microscopy, Electron
;
Myosin Heavy Chains/biosynthesis
;
S100 Calcium Binding Protein G/biosynthesis
;
Saccule and Utricle/embryology/metabolism/ultrastructure
;
Stem Cells/cytology
;
Transcription Factors/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
