Publication Date:
1999-03-19
Description:
In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1, 2, and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1, which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation. CLV3 encodes a small, predicted extracellular protein. CLV3 acts nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fletcher, J C -- Brand, U -- Running, M P -- Simon, R -- Meyerowitz, E M -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1911-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10082464" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Arabidopsis/*cytology/genetics/growth & development/metabolism
;
*Arabidopsis Proteins
;
Cell Differentiation
;
Cell Division
;
Cloning, Molecular
;
Gene Expression Regulation, Plant
;
Genes, Plant
;
In Situ Hybridization
;
Ligands
;
Meristem/*cytology/growth & development/metabolism
;
Molecular Sequence Data
;
Mutation
;
Phenotype
;
Plant Proteins/chemistry/genetics/*metabolism
;
Plant Shoots/cytology
;
RNA, Messenger/genetics/metabolism
;
RNA, Plant/genetics/metabolism
;
Receptor Protein-Tyrosine Kinases/genetics/metabolism
;
Recombinant Fusion Proteins/metabolism
;
*Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
