Publication Date:
1999-03-12
Description:
A central question in immunology is the origin of long-lived T cell memory that confers protection against recurrent infection. The differentiation of naive T cell receptor transgenic CD8+ cells into effector cytotoxic T lymphocytes (CTLs) and memory CD8+ cells was studied. Memory CD8+ cells that were generated after strong antigenic stimulation were the progeny of cytotoxic effectors and retained antigen-specific cytolytic activity 10 weeks after adoptive transfer to antigen-free recipient mice. Thus, potential vaccines based on CTL memory will require the differentiation of naive cells into post-effector memory T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Opferman, J T -- Ober, B T -- Ashton-Rickardt, P G -- 5T32 AI07090/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1999 Mar 12;283(5408):1745-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Committee on Immunology, Department of Pathology, Committee on Developmental Biology, The University of Chicago, Gwen Knapp Center for Lupus and Immunology Research, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10073942" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
Apoptosis
;
CD8-Positive T-Lymphocytes/*cytology/*immunology
;
Cell Differentiation
;
Cell Division
;
Cell Lineage
;
Cells, Cultured
;
Cytotoxicity, Immunologic
;
Dose-Response Relationship, Immunologic
;
H-Y Antigen/immunology
;
*Immunologic Memory
;
Lymphocyte Activation
;
Membrane Glycoproteins/metabolism
;
Mice
;
Mice, Transgenic
;
Perforin
;
Pore Forming Cytotoxic Proteins
;
T-Lymphocyte Subsets/cytology/*immunology
;
T-Lymphocytes, Cytotoxic/cytology/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
