Publication Date:
2016-01-23
Description:
Consolation behavior toward distressed others is common in humans and great apes, yet our ability to explore the biological mechanisms underlying this behavior is limited by its apparent absence in laboratory animals. Here, we provide empirical evidence that a rodent species, the highly social and monogamous prairie vole (Microtus ochrogaster), greatly increases partner-directed grooming toward familiar conspecifics (but not strangers) that have experienced an unobserved stressor, providing social buffering. Prairie voles also match the fear response, anxiety-related behaviors, and corticosterone increase of the stressed cagemate, suggesting an empathy mechanism. Exposure to the stressed cagemate increases activity in the anterior cingulate cortex, and oxytocin receptor antagonist infused into this region abolishes the partner-directed response, showing conserved neural mechanisms between prairie vole and human.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737486/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737486/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burkett, J P -- Andari, E -- Johnson, Z V -- Curry, D C -- de Waal, F B M -- Young, L J -- 1P50MH100023/MH/NIMH NIH HHS/ -- F31 MH102911-01/MH/NIMH NIH HHS/ -- F32 HD008702/HD/NICHD NIH HHS/ -- P50 MH100023/MH/NIMH NIH HHS/ -- P51 OD011132/OD/NIH HHS/ -- P51OD011132/OD/NIH HHS/ -- R01 MH096983/MH/NIMH NIH HHS/ -- R01MH096983/MH/NIMH NIH HHS/ -- T32GM08605-10/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):375-8. doi: 10.1126/science.aac4785.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA, USA. Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA. Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. jpburke@emory.edu lyoun03@emory.edu. ; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA, USA. Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA. Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. ; Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA. Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. ; Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA. Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Utrecht University, Utrecht, Netherlands. ; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA, USA. Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA. Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Department of Psychiatry, School of Medicine, Emory University, Atlanta, GA, USA. jpburke@emory.edu lyoun03@emory.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26798013" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anxiety/psychology
;
Anxiety, Separation/psychology
;
Arvicolinae/blood/physiology/*psychology
;
Corticosterone/blood
;
Emotions/physiology
;
Female
;
*Helping Behavior
;
Injections, Intraventricular
;
Male
;
Oxytocin/administration & dosage/*physiology
;
Stress, Psychological/psychology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
