Publication Date:
2015-07-25
Description:
Development of the cerebral cortex is influenced by sensory experience during distinct phases of postnatal development known as critical periods. Disruption of experience during a critical period produces neurons that lack specificity for particular stimulus features, such as location in the somatosensory system. Synaptic plasticity is the agent by which sensory experience affects cortical development. Here, we describe, in mice, a developmental critical period that affects plasticity itself. Transient neonatal disruption of signaling via the C-terminal domain of "disrupted in schizophrenia 1" (DISC1)-a molecule implicated in psychiatric disorders-resulted in a lack of long-term potentiation (LTP) (persistent strengthening of synapses) and experience-dependent potentiation in adulthood. Long-term depression (LTD) (selective weakening of specific sets of synapses) and reversal of LTD were present, although impaired, in adolescence and absent in adulthood. These changes may form the basis for the cognitive deficits associated with mutations in DISC1 and the delayed onset of a range of psychiatric symptoms in late adolescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenhill, Stuart D -- Juczewski, Konrad -- de Haan, Annelies M -- Seaton, Gillian -- Fox, Kevin -- Hardingham, Neil R -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2015 Jul 24;349(6246):424-7. doi: 10.1126/science.aaa8481.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biosciences, Cardiff University, Cardiff, CF23 3AX, UK. ; National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA. ; School of Biosciences, Cardiff University, Cardiff, CF23 3AX, UK. sbinrh@cardiff.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26206934" target="_blank"〉PubMed〈/a〉
Keywords:
Age of Onset
;
Animals
;
Cerebral Cortex/*growth & development/physiopathology
;
Cognition Disorders/genetics/physiopathology
;
Long-Term Potentiation/drug effects/*genetics
;
Mental Disorders/*genetics/physiopathology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Mutation
;
Nerve Tissue Proteins/*genetics
;
Neuronal Plasticity/drug effects/*genetics
;
Synapses/drug effects/physiology
;
Tamoxifen/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
