Publication Date:
2013-10-12
Description:
Lymphocytes face major metabolic challenges upon activation. They must meet the bioenergetic and biosynthetic demands of increased cell proliferation and also adapt to changing environmental conditions, in which nutrients and oxygen may be limiting. An emerging theme in immunology is that metabolic reprogramming and lymphocyte activation are intricately linked. However, why T cells adopt specific metabolic programs and the impact that these programs have on T cell function and, ultimately, immunological outcome remain unclear. Research on tumor cell metabolism has provided valuable insight into metabolic pathways important for cell proliferation and the influence of metabolites themselves on signal transduction and epigenetic programming. In this Review, we highlight emerging concepts regarding metabolic reprogramming in proliferating cells and discuss their potential impact on T cell fate and function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486656/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486656/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearce, Erika L -- Poffenberger, Maya C -- Chang, Chih-Hao -- Jones, Russell G -- AI091965/AI/NIAID NIH HHS/ -- CA158823/CA/NCI NIH HHS/ -- MOP-93799/Canadian Institutes of Health Research/Canada -- R01 AI091965/AI/NIAID NIH HHS/ -- R01 CA181125/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2013 Oct 11;342(6155):1242454. doi: 10.1126/science.1242454.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. erikapearce@path.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24115444" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carrier Proteins/metabolism
;
Cell Differentiation
;
Cell Proliferation
;
*Citric Acid Cycle
;
Gene Expression Regulation
;
*Glycolysis
;
Humans
;
Ketoglutaric Acids/metabolism
;
*Lymphocyte Activation
;
Membrane Proteins/metabolism
;
Mitochondria/immunology/metabolism
;
Neoplasms/immunology/metabolism
;
Protein Kinases/metabolism
;
Protein-Serine-Threonine Kinases/metabolism
;
T-Lymphocytes/*immunology/*metabolism
;
Thyroid Hormones/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
