Publication Date:
2013-03-23
Description:
Cardiac pacemaker cells autonomously generate electrical impulses that initiate and maintain the rhythmic contraction of the heart. Although the majority of heart cells are thought to originate from the primary and secondary heart fields, we found that chick pacemaker cells arise from a discrete region of mesoderm outside of these fields. Shortly after gastrulation, canonical Wnts promote the recruitment of mesodermal cells within this region into the pacemaker lineage. These findings suggest that cardiac pacemaker cells are physically segregated and molecularly programmed in a tertiary heart field prior to the onset of cardiac morphogenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651765/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651765/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bressan, Michael -- Liu, Gary -- Mikawa, Takashi -- R01 HL093566/HL/NHLBI NIH HHS/ -- R01 HL112268/HL/NHLBI NIH HHS/ -- R01HL093566/HL/NHLBI NIH HHS/ -- R01HL112268/HL/NHLBI NIH HHS/ -- R37 HL078921/HL/NHLBI NIH HHS/ -- T32 HL007544/HL/NHLBI NIH HHS/ -- T32HL007544/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2013 May 10;340(6133):744-8. doi: 10.1126/science.1232877. Epub 2013 Mar 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23519212" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Cell Lineage
;
Chick Embryo
;
Cues
;
Gastrulation
;
Heart/*embryology/physiology
;
*Heart Rate
;
Mesoderm/cytology/*physiology
;
Myocytes, Cardiac/*physiology
;
Signal Transduction
;
Sinoatrial Node/cytology/embryology/*physiology
;
Wnt Proteins/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
