Publication Date:
2011-05-28
Description:
There is a general need for the engineering of protein-like molecules that organize into geometrically specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multilayered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recognition and favorable intersubunit packing interactions. This procedure is exemplified in the design of peptides that assemble into a tubular structure surrounding single-walled carbon nanotubes (SWNTs). The geometrically defined, virus-like coating created by these peptides converts the smooth surfaces of SWNTs into highly textured assemblies with long-scale order, capable of directing the assembly of gold nanoparticles into helical arrays along the SWNT axis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264056/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264056/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grigoryan, Gevorg -- Kim, Yong Ho -- Acharya, Rudresh -- Axelrod, Kevin -- Jain, Rishabh M -- Willis, Lauren -- Drndic, Marija -- Kikkawa, James M -- DeGrado, William F -- 5F32GM084631-02/GM/NIGMS NIH HHS/ -- F32 GM084631/GM/NIGMS NIH HHS/ -- F32 GM084631-02/GM/NIGMS NIH HHS/ -- GM54616/GM/NIGMS NIH HHS/ -- R37 GM054616/GM/NIGMS NIH HHS/ -- R37 GM054616-17/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 May 27;332(6033):1071-6. doi: 10.1126/science.1198841.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617073" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Computer Simulation
;
Gold
;
Metal Nanoparticles
;
Models, Molecular
;
*Nanotubes, Carbon
;
Peptides/*chemistry
;
Protein Binding
;
Protein Conformation
;
*Protein Engineering
;
Protein Stability
;
Protein Structure, Secondary
;
Solubility
;
Surface Properties
;
Viruses
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
