Publication Date:
2011-01-08
Description:
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089969/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089969/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vivier, Eric -- Raulet, David H -- Moretta, Alessandro -- Caligiuri, Michael A -- Zitvogel, Laurence -- Lanier, Lewis L -- Yokoyama, Wayne M -- Ugolini, Sophie -- AI035021/AI/NIAID NIH HHS/ -- AI039642/AI/NIAID NIH HHS/ -- AI066897/AI/NIAID NIH HHS/ -- AI068129/AI/NIAID NIH HHS/ -- AI33903/AI/NIAID NIH HHS/ -- AI34385/AI/NIAID NIH HHS/ -- AI51345/AI/NIAID NIH HHS/ -- AI5716/AI/NIAID NIH HHS/ -- CA093678/CA/NCI NIH HHS/ -- CA095137/CA/NCI NIH HHS/ -- CA16058/CA/NCI NIH HHS/ -- CA68458/CA/NCI NIH HHS/ -- CA95426/CA/NCI NIH HHS/ -- R01 AI035021/AI/NIAID NIH HHS/ -- R01 AI035021-11/AI/NIAID NIH HHS/ -- R01 AI039642/AI/NIAID NIH HHS/ -- R01 AI039642-11/AI/NIAID NIH HHS/ -- R01 CA093678/CA/NCI NIH HHS/ -- R01 CA093678-10/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):44-9. doi: 10.1126/science.1198687.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre d'Immunologie de Marseille-Luminy (CIML), Universite de la Mediterranee UM 631, Campus de Luminy, 13288 Marseille, France. vivier@ciml.univ-mrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212348" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptive Immunity
;
Animals
;
Humans
;
*Immunity, Innate
;
Immunologic Memory
;
Killer Cells, Natural/*immunology
;
Neoplasms/immunology/therapy
;
Receptors, Immunologic/immunology/metabolism
;
Self Tolerance
;
Virus Diseases/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
