Publication Date:
2010-09-11
Description:
Fungal degradation of plant biomass may provide insights for improving cellulosic biofuel production. We show that the model cellulolytic fungus Neurospora crassa relies on a high-affinity cellodextrin transport system for rapid growth on cellulose. Reconstitution of the N. crassa cellodextrin transport system in Saccharomyces cerevisiae promotes efficient growth of this yeast on cellodextrins. In simultaneous saccharification and fermentation experiments, the engineered yeast strains more rapidly convert cellulose to ethanol when compared with yeast lacking this system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galazka, Jonathan M -- Tian, Chaoguang -- Beeson, William T -- Martinez, Bruno -- Glass, N Louise -- Cate, Jamie H D -- New York, N.Y. -- Science. 2010 Oct 1;330(6000):84-6. doi: 10.1126/science.1192838. Epub 2010 Sep 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20829451" target="_blank"〉PubMed〈/a〉
Keywords:
*Biofuels
;
Biological Transport
;
Biomass
;
Cellobiose/metabolism
;
Cellulase/metabolism
;
Cellulose/*analogs & derivatives/*metabolism
;
Dextrins/*metabolism
;
Ethanol/metabolism
;
Fermentation
;
Fungal Proteins/genetics/*metabolism
;
Genetic Engineering
;
Kinetics
;
Membrane Transport Proteins/genetics/*metabolism
;
Neurospora crassa/genetics/growth & development/*metabolism
;
Saccharomyces cerevisiae/genetics/growth & development/*metabolism
;
Saccharomyces cerevisiae Proteins/metabolism
;
beta-Glucosidase/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
