Publication Date:
2009-04-11
Description:
In vertebrates, the readily apparent left/right (L/R) anatomical asymmetries of the internal organs can be traced to molecular events initiated at or near the time of gastrulation. However, the earliest steps of this process do not seem to be universally conserved. In particular, how this axis is first defined in chicks has remained problematic. Here we show that asymmetric cell rearrangements take place within chick embryos, creating a leftward movement of cells around the node. It is the relative displacement of cells expressing sonic hedgehog (Shh) and fibroblast growth factor 8 (Fgf8) that is responsible for establishing their asymmetric expression patterns. The creation of asymmetric expression domains as a passive effect of cell movements represents an alternative strategy for breaking L/R symmetry in gene activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993078/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993078/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gros, Jerome -- Feistel, Kerstin -- Viebahn, Christoph -- Blum, Martin -- Tabin, Clifford J -- R01 HD045499/HD/NICHD NIH HHS/ -- R01 HD045499-06/HD/NICHD NIH HHS/ -- R01-HD045499/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2009 May 15;324(5929):941-4. doi: 10.1126/science.1172478. Epub 2009 Apr 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19359542" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
*Body Patterning
;
*Cell Movement
;
Chick Embryo
;
Fibroblast Growth Factor 8/genetics
;
*Gastrulation
;
*Gene Expression
;
Gene Expression Profiling
;
Hedgehog Proteins/genetics
;
Molecular Sequence Data
;
Organizers, Embryonic/*cytology/embryology/*metabolism
;
Primitive Streak/*cytology/embryology/metabolism
;
Swine/embryology
;
Tissue Culture Techniques
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
