Publication Date:
2008-12-06
Description:
Female meiotic drive, in which paired chromosomes compete for access to the egg, is a potentially powerful but rarely documented evolutionary force. In interspecific monkeyflower (Mimulus) hybrids, a driving M. guttatus allele (D) exhibits a 98:2 transmission advantage via female meiosis. We show that extreme interspecific drive is most likely caused by divergence in centromere-associated repeat domains and document cytogenetic and functional polymorphism for drive within a population of M. guttatus. In conspecific crosses, D had a 58:42 transmission advantage over nondriving alternative alleles. However, individuals homozygous for the driving allele suffered reduced pollen viability. These fitness effects and molecular population genetic data suggest that balancing selection prevents the fixation or loss of D and that selfish chromosomal transmission may affect both individual fitness and population genetic load.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, Lila -- Saunders, Arpiar -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1559-62. doi: 10.1126/science.1161406.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA. lila.fishman@mso.umt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056989" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Base Sequence
;
Biological Evolution
;
Centromere/*physiology
;
Chromosome Segregation
;
Chromosomes, Plant/*physiology
;
Crosses, Genetic
;
Genetic Markers
;
Heterozygote
;
Hybridization, Genetic
;
Linkage Disequilibrium
;
*Meiosis
;
Mimulus/*genetics/physiology
;
Molecular Sequence Data
;
Polymorphism, Genetic
;
Repetitive Sequences, Nucleic Acid
;
Selection, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
