Publication Date:
2006-01-28
Description:
The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Obenauer, John C -- Denson, Jackie -- Mehta, Perdeep K -- Su, Xiaoping -- Mukatira, Suraj -- Finkelstein, David B -- Xu, Xiequn -- Wang, Jinhua -- Ma, Jing -- Fan, Yiping -- Rakestraw, Karen M -- Webster, Robert G -- Hoffmann, Erich -- Krauss, Scott -- Zheng, Jie -- Zhang, Ziwei -- Naeve, Clayton W -- AI95357/AI/NIAID NIH HHS/ -- CA 21765/CA/NCI NIH HHS/ -- R01 GM061739/GM/NIGMS NIH HHS/ -- R01 GM069916/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Mar 17;311(5767):1576-80. Epub 2006 Jan 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16439620" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Birds/virology
;
Computational Biology
;
*Genes, Viral
;
Genome, Viral
;
Humans
;
Influenza A Virus, H1N1 Subtype/genetics
;
Influenza A Virus, H2N2 Subtype/genetics
;
Influenza A Virus, H3N2 Subtype/genetics
;
Influenza A Virus, H3N8 Subtype/genetics
;
Influenza A Virus, H5N1 Subtype/chemistry/*genetics/pathogenicity
;
Influenza A Virus, H5N2 Subtype/genetics
;
Influenza A Virus, H7N7 Subtype/genetics
;
Influenza A Virus, H9N2 Subtype/genetics
;
Influenza A virus/chemistry/*genetics/isolation & purification/pathogenicity
;
Influenza in Birds/virology
;
Influenza, Human/virology
;
Molecular Sequence Data
;
Mutation
;
Phylogeny
;
RNA, Viral/genetics
;
Reassortant Viruses/genetics
;
Sequence Analysis, DNA
;
Viral Nonstructural Proteins/*chemistry/genetics
;
Viral Proteins/chemistry/genetics
;
Virulence Factors/*chemistry/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
