Publication Date:
2005-06-04
Description:
Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Changeux, Jean-Pierre -- Edelstein, Stuart J -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1424-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Receptors and Cognition, Institut Pasteur, 75724 Paris Cedex 15, France. changeux@pasteur.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933191" target="_blank"〉PubMed〈/a〉
Keywords:
*Allosteric Regulation
;
Binding Sites
;
Enzymes/metabolism
;
Ligands
;
Models, Biological
;
Protein Binding
;
Protein Conformation
;
Protein Structure, Tertiary
;
Receptors, Cell Surface/physiology
;
Signal Transduction/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
