Publication Date:
2004-08-25
Description:
Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Genes preferentially expressed in oocytes, including Oct4 and Gdf9, are down-regulated in Nobox-/- mice, whereas ubiquitous genes such as Bmp4, Kit, and Bax remain unaffected. Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajkovic, Aleksandar -- Pangas, Stephanie A -- Ballow, Daniel -- Suzumori, Nobuhiro -- Matzuk, Martin M -- HD007165/HD/NICHD NIH HHS/ -- HD01426/HD/NICHD NIH HHS/ -- HD33438/HD/NICHD NIH HHS/ -- HD42500/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 Aug 20;305(5687):1157-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA. rajkovic@bcm.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15326356" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
Apoptosis
;
Embryonic and Fetal Development/genetics
;
Female
;
Fertility
;
Gene Deletion
;
*Gene Expression Regulation, Developmental
;
Gene Targeting
;
*Genes, Homeobox
;
Germ Cells/cytology/physiology
;
Homeodomain Proteins/*genetics/*physiology
;
Male
;
Meiosis
;
Mice
;
Mice, Inbred C57BL
;
Oocytes/*physiology
;
Oogenesis
;
Ovarian Follicle/*physiology
;
Ovary/cytology/embryology/physiology
;
Transcription Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
